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TAK-243 preferentially certain to UBA1 above the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered levels of ubiquitylated proteins, enhanced markers of proteotoxic worry and DNA problems worry. In vivo, TAK-243 diminished leukemic load and specific leukemic stem cells without evidence https://fluoxetinehydrochloride55432.blogolenta.com/25832656/detailed-notes-on-sinefungin

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