Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interac... https://rudyardb974udl2.empirewiki.com/user