There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to lessen afferent pain transmission and produce analgesia. Thus, drugs like clonidine that focus on alpha-2 receptors can affect the transmission of suffering. Clonidine is dispersed in breast milk; https://socialbuzzfeed.com/story5243625/the-5-second-trick-for-onolidine