Very poor/Substantial Metabolizers, CYP2D6 The formation from the Lively metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around seven% with the populace has reduced activity in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These people today are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, among the https://clinto998lyl4.wikicommunications.com/user